RESEARCH

Clinical research on mushrooms is expanding rapidly across the globe. Scientists and clinicians are exploring how these natural compounds may support mental health, neuroplasticity, and overall well-being.

Below you’ll find a selection of peer-reviewed research papers and clinical trials that highlight recent discoveries in mushroom-based therapy.

We regularly update this page with new publications as the field evolves — check back often to stay informed about the latest psilocybin research and scientific breakthroughs.

Alcohol Use Disorder — NYU / U.S. Academic Sites

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder.
Published: August 24, 2022
Article: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625 (JAMA Network)

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder — Johns Hopkins

Randomized clinical trial showing rapid, durable antidepressant effects in patients with MDD.

Published: November 4, 2020
Article: https://www.nature.com/articles/s41514-025-00244-x (JAMA Network)
Full text via PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7643046/ (PMC)

Clinical Research Paper on “Natalensis” – Ochraceocentrata

Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom

Published: August 31, 2020
Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC7570254/

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